Authors
Msilikale Walter Manyiri, Georg Loss, Susanne P Martin-Herz, Deborah Sumari, Nicolaus Gutapaka, Thabit Athuman, Sylvester Simando, Sylvia Jebiwott, Xue Wu, Karim Manji, Ally Olotu, Michelle S Hsiang, Günther Fink
Published in
PloS one. Volume 21. Issue 7. Pages e0354139. Epub Jul 27, 2026.
Abstract
Socioeconomic disparities in children's neurodevelopment constitute a critical yet understudied developmental challenge in low- and middle-income countries (LMICs), yet longitudinal evidence from Sub-Saharan Africa (SSA) remains limited. This study aimed to evaluate the relationship between household wealth and neurocognitive trajectories in a cohort of Tanzanian children aged 6 months to 10 years.
We randomly selected 590 children aged 6 months to 10 years in Bagamoyo district, a low to moderate-malaria-endemic area in Tanzania. Participants completed comprehensive, age-appropriate neurodevelopmental assessments. The family's socioeconomic status was derived from their household assets. Standardized, age-adjusted neurodevelopmental scores were regressed on socioeconomic status tertiles and by developmental periods: early childhood (6 months-3 years), preschool (4-5 years), and school age (6-10 years).
While children from high- and low-Socioeconomic status (SES) families start with similar neurodevelopmental scores, a significant and sustained gap begins to emerge around age 2 years. This divergence results in a substantial disadvantage for children from the poorest households, with scores showing a difference of -0.36 Standard Deviation (SD) (95% CI: -0.64 to -0.08) during the preschool years and -0.41 SD (95% CI: -0.73 to -0.09) at school age.
Our results suggest that programs targeting the preschool period may be most effective in mitigating disparities in neurodevelopment.
PMID:
42507661
Bibliographic data and abstract were imported from PubMed on 28 Jul 2026.
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