Risk factors for late intraocular lens dislocation: a systematic review and meta-analysis.

Authors

Natalia S Anisimova, Maxim V Ivanov, Lisa B Arbisser, Valery P Erichev

Published in

Journal of cataract and refractive surgery. Jul 21, 2026. Epub Jul 21, 2026.

Abstract

To quantify associations between potential risk factors and late intraocular lens (IOL) dislocation after uncomplicated phacoemulsification with IOL implantation.
Late IOL dislocation is an uncommon but clinically important long-term complication of cataract surgery. Although several predisposing conditions have been described, their relative contribution has not been comprehensively quantified.
A systematic review and meta-analysis were performed according to PRISMA. The study protocol was prospectively registered on PROSPERO (CRD420261328390). MEDLINE, Google Scholar, ScienceDirect, and Cochrane Library were searched for English- and Russian-language studies published from 2000 to 2025. Comparative observational studies were included in the meta-analysis; additional non-comparative studies were used for descriptive synthesis of prevalence data. Risk of bias was assessed with the Newcastle-Ottawa Scale. Random-effects models were used to pool odds ratio (OR) with 95% confidence interval (CI).
Eight comparative studies were included in the meta-analysis and 28 non-comparative studies in descriptive synthesis. The strongest associations were found for zonular weakness (OR 8.04, 95% CI 5.27-12.28), ocular trauma (OR 5.98, 95% CI 2.16-16.52), uveitis (OR 5.73, 95% CI 2.23-14.68), and pseudoexfoliation syndrome (OR 5.72, 95% CI 3.23-10.15). Myopia (OR 3.32, 95% CI 1.38-7.97) and glaucoma (OR 2.60, 95% CI 1.46-4.60) showed moderate associations, whereas previous vitrectomy and male sex were not statistically significant.
Late IOL dislocation is most strongly associated with structural and inflammatory damage to the capsular-zonular complex. High prevalence of a factor among cases does not necessarily indicate independent pathogenetic significance.

PMID:
42507533
Bibliographic data and abstract were imported from PubMed on 28 Jul 2026.

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