Pre-transfusion platelet counts and bleeding in very low birth weight infants (78/150 characters).

Authors

Elizabeth F Stone, Rebecca Birch, Jeanne E Hendrickson, Erika M Edwards, Ruchika Goel, Eldad A Hod, Matthew Karafin, Oliver Karam, Naomi L C Luban, Jennifer McIntosh, Gisela Marrero-Rivera, Marianne E Nellis, Jeffrey VanWormer, Nalan Yurtsever, Cassandra D Josephson, Martha Sola-Visner, Ravi M Patel, NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-P (REDS-IV-P)

Published in

Journal of perinatology : official journal of the California Perinatal Association. Jul 27, 2026. Epub Jul 27, 2026.

Abstract

Platelet transfusion thresholds for very low birth weight (VLBW, <1500 g) infants vary widely, and the role of bleeding on platelet transfusion thresholds is uncertain.
This observational birth cohort study of VLBW infants born in 7 hospitals across the US examined pre-transfusion platelet counts in infants with and without bleeding who received at least 1 platelet transfusion in the first 3 weeks of life using mixed effect linear regression models.
Of the 210 transfused infants, most (76%) had bleeding; intraventricular hemorrhage (IVH) was the most common (61%) bleeding type. Pre-transfusion platelet counts were not different among infants with or without bleeding diagnoses (56.3 vs 58.5 × 10³/µL, respectively; P = 0.7). However, infants with severe IVH had higher platelet counts (68.9 × 10³/µL) compared to the entire cohort (53.5 × 10³/µL, P = 0.01).
Infants with or without bleeding diagnoses had similar pre-transfusion platelet counts; infants with severe IVH had higher pre-transfusion platelet counts.

PMID:
42509307
Bibliographic data and abstract were imported from PubMed on 28 Jul 2026.

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