Characteristics of Clinical Response in Patients With Chronic Myeloid Leukemia With an ABL1 In-Frame Exon 4 Deletion: A Multicenter Retrospective Study.

Authors

Yuto Kaneda, Nobuhiro Kanemura, Yoshikazu Ikoma, Takuro Matsumoto, Nobuhiko Nakamura, Hiroshi Nakamura, Senji Kasahara, Kenji Fukuno, Yutaka Tsukune, Tomoiku Takaku, Masahito Shimizu

Published in

EJHaem. Volume 7. Issue 4. Pages e70361. Epub Jul 27, 2026.

Abstract

In-frame Exon 4 deletion (p.L184_K274del) is a rare ABL1 splicing variant in chronic myeloid leukemia (CML), the clinical significance of which remains unclear.
We retrospectively analyzed seven chronic-phase CML patients with this variant, identified by Sanger sequencing during routine monitoring of atypically slow molecular responses.
All patients achieved hematologic responses; molecular responses, although attained, were often delayed. No patient progressed to advanced phase disease during a median follow-up of 39.0 months.
Detection of this kinase-inactive variant should not, in itself, be regarded as a definitive resistance mechanism. Larger collaborative studies using quantitative methodologies are needed.
The authors have confirmed clinical trial registration is not needed for this submission.

PMID:
42517020
Bibliographic data and abstract were imported from PubMed on 28 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.