Diagnostic value of EBUS-guided transbronchial mediastinal cryobiopsy versus conventional bronchoscopic approaches for stage I/II sarcoidosis: DETECTION-SAR I.

Authors

Zhuofan Li, Quncheng Zhang, Fei Tang, Ye Fan, Mingming Deng, Yunchao Su, Ziwen Zheng, Run Tong, Guowu Zhou, José M Porcel, Gang Hou

Published in

ERJ open research. Volume 12. Issue 4. Epub Jul 27, 2026.

Abstract

A direct comparison between endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), combined with endobronchial biopsy (EBB) and/or transbronchial lung biopsy (TBLB), and endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TBMC) for diagnosing sarcoidosis has not been conducted. The aim of the study was to evaluate whether EBUS-TBMC has the same or better diagnostic yield for sarcoidosis than EBUS-TBNA combined with standard bronchoscopic modalities (EBB and/or TBLB).
The records of patients with stage I/II sarcoidosis from four centres in China who underwent EBUS-TBMC or EBUS-TBNA combined with EBB and/or TBLB were retrospectively examined. Data on bronchoscopy examination records, pathological results of bronchoscopic biopsy modalities and postprocedural complications were collected. The outcomes were diagnostic yield and postprocedural complications.
A total of 438 patients were included in this study. Compared with EBUS-TBNA, EBUS-TBMC had greater diagnostic yield for sarcoidosis (95.1% versus 84.1%, p<0.001). The diagnostic yield of EBUS-TBNA combined with EBB and/or TBLB was greater than that of EBUS-TBNA alone. No significant differences in diagnostic yield were detected between EBUS-TBMC and EBUS-TBNA combined with EBB and/or TBLB or between EBUS-TBMC and EBUS-TBMC combined with EBB and/or TBLB. No major adverse complications related to the bronchoscopic procedure were observed.
EBUS-TBMC exhibited diagnostic yield equivalent to that of EBUS-TBNA combined with EBB and/or TBLB, and superior to that of EBUS-TBNA alone in stage I/II sarcoidosis. The addition of EBB and/or TBLB to EBUS-TBMC did not improve the diagnostic yield of EBUS-TBMC for sarcoidosis. EBUS-TBMC has the potential to reduce the need for EBB and TBLB.

PMID:
42516908
Bibliographic data and abstract were imported from PubMed on 28 Jul 2026.

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