Factors Associated with Favorable One-Year Outcomes After PreserFlo MicroShunt Implantation: Insights from Anterior Segment Optical Coherence Tomography.

Authors

Takahiro Minami, Daisuke Takemoto, Taro Muroya, Sachiko Udagawa, Shunsuke Tsuchiya, Kimikazu Sakaguchi, Ryotaro Wajima, Yoko Yamashita, Kazuhisa Sugiyama, Tomomi Higashide

Published in

Advances in therapy. Jul 28, 2026. Epub Jul 28, 2026.

Abstract

This study aimed to identify factors associated with favorable 1-year surgical outcomes after PreserFlo MicroShunt (PMS) implantation, with a particular focus on baseline ocular anatomy and postoperative filtration patterns assessed by anterior segment optical coherence tomography (AS-OCT).
This cohort study included individuals with primary open-angle or exfoliation glaucoma who underwent PMS implantation. AS-OCT was performed 1 month postoperatively. Surgical success was defined by hypertensive thresholds of 12 mmHg (A), 15 mmHg (B), and 18 mmHg (C), with an intraocular pressure (IOP) reduction of ≥ 20% from baseline. Each criterion had a hypotensive limit of 6 mmHg. Multivariable Cox proportional hazards models were used to evaluate factors associated with favorable outcomes, considering both hypertensive and hypotensive failure limits.
Eighty-eight eyes were analyzed. Median IOP decreased from 19 mmHg (interquartile range: 16-23.8) to 10 mmHg (8-13) at 12 months (p < 0.001). Qualified success rates at 12 months were 56.8% for criterion A, 70.5% for criterion B, and 73.9% for criterion C. Filtration toward the corneal limbus on AS-OCT was associated with a lower risk of hypertensive failure across all criteria (HR, 0.28-0.57; p = 0.008-0.031). Longer axial length was significant for criteria B and C (HR, 0.70 and 0.77; p = 0.002 and 0.008). Older age and exfoliation glaucoma were risk factors for hypotensive failure (HR, 1.05 and 3.75; p = 0.01 and 0.006).
Both baseline ocular anatomy, represented by axial length, and filtration toward the corneal limbus on AS-OCT were independently associated with favorable 1-year outcomes following PMS implantation. Integrating preoperative anatomical assessment with early postoperative imaging findings may help clinicians better understand individual surgical responses.

PMID:
42518141
Bibliographic data and abstract were imported from PubMed on 28 Jul 2026.

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