Authors
Mohamed Ahmed El-Baz, Somaia Abdel Samie El Wan, Rodina Sobhy Mohamed, Eman Khaled Gouda, Yousra Mohsen Kamal Ali El-Tabakh, Eman Gamal Abdul Rahman
Published in
Indian journal of pediatrics. Jul 28, 2026. Epub Jul 28, 2026.
Abstract
To evaluate the effect of omega-3 supplementation on heart rate (HR) control and heart rate variability (HRV) in children with inappropriate sinus tachycardia (IST).
This prospective randomized controlled trial included 60 children (aged 12-16 y) diagnosed with IST. Participants were randomized into two groups: Group A received omega-3 supplementation for 3 mo, while Group B received standard follow-up without treatment. Baseline and post-treatment HR, HRV parameters [Standard deviation of NN intervals (SDNN), Root mean square of successive differences (RMSSD), pNN50], and clinical outcomes were assessed using 24-h Holter monitoring and validated scales.
After 3 mo, the omega-3 group showed significant reductions in maximum HR (from 160.5 ± 17.9 to 142.2 ± 15.7 bpm, p = 0.000) and average HR (from 98.9 ± 4.7 to 90.7 ± 5.5 bpm, p = 0.000). HRV indices also improved significantly: SDNN (p = 0.000), RMSD (p = 0.000), and pNN50 (p = 0.000). In contrast, no significant changes were observed in the control group. Clinical improvement was significantly higher in the omega-3 group (63.3% marked improvement) compared to controls (p <0.001). Obesity (p = 0.049) and pre-hypertension (p <0.001) were associated with poor response to omega-3 therapy. No significant differences in anxiety scores were found between groups.
Omega-3 supplementation significantly improved HR control and HRV in pediatric IST patients. Obesity and elevated blood pressure may limit treatment efficacy.
PMID:
42518088
Bibliographic data and abstract were imported from PubMed on 28 Jul 2026.
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