Authors
Yujiao Hu, Hao Ding, Lijing Zou, Zhuo Wen, Hongming Wu, Tingting Ni, Lin He, Qi Gao, Han Cao, Junyu Zhou, Jiajun Chen, Baochun Jiang, Shuang Qiu, Lina Yu, Min Yan
Published in
Pain. Jul 23, 2026. Epub Jul 23, 2026.
Abstract
Although cortical-thalamic projections contribute to pain modulation, their downstream targets and functional roles are not well defined. Here, we show that glutamatergic neurons in the hindlimb region of primary somatosensory cortex (S1HLGlu) project to a subset of glutamatergic neurons in the ventral posterolateral thalamic nucleus (VPLGlu) that are anatomically separated from VPL neurons receiving peripheral afferent inputs. These VPLGlu neurons preferentially innervate S1HLGlu neurons, forming a recurrent glutamatergic corticothalamocortical pathway. Optogenetic and chemogenetic activation of the S1HLGlu-VPLGlu-S1HLGlu pathway reduced mechanical withdrawal thresholds under baseline conditions, whereas circuit inhibition alleviated mechanical allodynia and spontaneous pain in the spared nerve injury model without altering baseline nociception of mice. In vivo fiber photometry further demonstrated that this pathway enhanced S1HLGlu responses to normally subthreshold mechanical stimuli, suggesting a role in sensory amplification. Together, these findings indicate that the S1HLGlu-VPLGlu-S1HLGlu pathway becomes pathologically engaged during neuropathic pain and contributes to mechanical hypersensitivity. This work provides mechanistic insight into corticothalamic involvement in cortical pain processing and highlights a selective excitatory pathway as a potential target for neuropathic pain intervention.
PMID:
42520165
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.
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