Design, Synthesis, and Fungicidal and Insecticidal Activities of Methoxyacrylate Derivatives via Linker Modification.

Authors

Dan Li, Ying Hou, Hongwei Li, Liqi Zhou, Letian Hu, Jiyong Liu

Published in

Chemistry & biodiversity. Volume 23. Issue 7. Pages e71505.

Abstract

To discover novel and highly effective pesticides with diverse structures, 16 new methoxyacrylate compounds were designed and synthesized based on linker modification. All target compounds were characterized by ¹H NMR, ¹³C NMR, and HRMS. Preliminary bioassay results indicated that some target compounds exhibited good fungicidal activity against Phakopsora pachyrhizi, Sphaerotheca fuliginea, and Pyricularia oryzae, as well as potent insecticidal activity against Plutella xylostella, Mythimna separata, and Aphis craccivora. Notably, compound 10b showed 100% control efficacy against Phakopsora pachyrhizi at 0.4 mg/L, 100% control efficacy against Sphaerotheca fuliginea at 25 mg/L, and 88.89% control efficacy against Pyricularia oryzae at 100 mg/L. Meanwhile, compound 10b exhibited 69.05% mortality against Aphis craccivora at 4 mg/L and 100% mortality against Mythimna separata at 10 mg/L, demonstrating broad-spectrum activity. These findings may provide valuable insights for the development of novel and highly effective methoxyacrylate derivatives.

PMID:
42520159
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.