Cryogel-based therapeutic platforms for disease modification in osteoarthritis.

Authors

Jewelia A Durant, Maria Eduarda Torres Gouveia, Aleyna E La Croix, Adithya R Puninchittaya, Katherine R Hixon

Published in

npj biomedical innovations. Volume 3. Issue 1. Jul 01, 2026. Epub Jul 01, 2026.

Abstract

Osteoarthritis (OA) is a leading cause of chronic pain and disability, and lacks disease-modifying therapies. Unlike conventional hydrogels, which suffer from poor mechanical robustness and limited retention, cryogels overcome existing limitations through their interconnected pore architecture, shape-memory behavior, and fatigue-resistant mechanics. Here, we review how cryogels are being engineered as platforms for stem cell delivery, bioactive molecule release, localized gene activation, and immunomodulation, and discuss key translation challenges.

PMID:
42387109
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.

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