The bile acid-sensive ion channel (BASIC) is expressed in pancreatic α-cells and involved in glucagon secretion.

Authors

Jingyu Yang, Stefan Gründer, Dominik Wiemuth

Published in

Pflugers Archiv : European journal of physiology. Volume 478. Issue 8. Jul 29, 2026. Epub Jul 29, 2026.

Abstract

Pancreatic α-cells play a key role in glucose homeostasis through glucagon secretion. Here, we discover that the bile acid-sensitive ion channel (BASIC), a Na⁺ channel of the DEG/ENaC family, has a hitherto unrecognized role in α-cell function. We found that BASIC is mainly expressed in glucagon-positive α-cells of mouse islets. Genetic ablation of BASIC in mice reduced α-cell number, glucagon expression, and glucagon serum levels. These dramatic changes were accompanied by disturbed expression of α-cell specific transcription factors. Our findings identify BASIC as a previously unknown regulator of α-cell physiology.

PMID:
42521859
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.

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