Racial and ethnic disparities in the cause of death for clear cell renal cell carcinoma.

Authors

Yingwei Xie, Yishan Zhang, Shuang Li, Li Chen, Yuexin Liu, Wenlian Xie, Zaosong Zheng, Hao Ping

Published in

Nature communications. Volume 17. Issue 1. Jul 28, 2026. Epub Jul 28, 2026.

Abstract

The trends and contributors of racial and ethnic disparities in causes of death among patients with clear cell renal cell carcinoma remain unclear. We analyse SEER data (2000-2019) and find that Black patients have the highest 5-year cumulative incidence of death (22.4% vs. 21.7% in whites). Despite a decreasing trend in mortality, the disparities persist between Black and white people (HR 1.15, 95% CI 1.09-1.22) and between AIAN and white people (1.25, 1.10-1.43). Disparities in death from cardiovascular disease between Black and white people increase over time. Stage at diagnosis, receipt of surgery, income, and geographic factors partially explain the observed disparities in mortality patterns. This study identifies specific, measurable contributors to mortality disparities, suggesting that interventions targeting earlier detection, equitable treatment, and socioeconomic barriers are needed.

PMID:
42521664
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.

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