Authors
Patrick E Sloan, Lila S Sanning, Caren Liviskie, Kristen Clark, Kylie Bushroe, Melissa Riley, Anna Lijowska, Jesse Vrecenak, Tasnim Najaf
Published in
Journal of perinatology : official journal of the California Perinatal Association. Jul 28, 2026. Epub Jul 28, 2026.
Abstract
Identify how a core congenital diaphragmatic hernia (CDH) team coupled with early recognition and treatment of cardiac dysfunction changed outcomes for infants with CDH.
A retrospective chart review compared a historical cohort from 2015-2019 (n = 51) with a post-guideline cohort from 2020-2025 (n = 53). Statistical analysis was performed with Fisher's exact, unpaired t-test, and Mann Whitney U-test.
Survival improved from 68.6% to 88.7% (p = 0.016) and ECMO utilization decreased, 51.0% to 26.4% (p = 0.015). Infants with cardiac dysfunction had increased survival (47.3% vs. 81.8%, p = 0.014) and less ECMO utilization (68.4% vs. 36.3%, p = 0.043). Vasoactive choices evolved with dopamine replaced by norepinephrine, low-dose epinephrine, or calcium gluconate. Inhaled nitric oxide (iNO) use in the first 48 h decreased significantly while prostaglandin E1 (PGE1) use increased.
We implemented a core CDH team focused on a generalizable, physiology-driven approach to identify and treat cardiac dysfunction using standard neonatal echocardiography to improve outcomes.
PMID:
42521741
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 2
- Comments 0