Authors
Fatema Akhter, Nourelhoda Alim, Tahsinul Haque, Mohammed Saad Alqarni, Khaled AlAkkam, Mohammed Alshammari, Sally Elhaddad, Farzana Akter Mony, Ahmed M Suleiman, Sanjay Rastogi
Published in
Oral diseases. Jul 28, 2026. Epub Jul 28, 2026.
Abstract
Oral potentially malignant disorders (OPMDs) are clinically significant lesions associated with malignant change, while malignant lesions represent established disease. Histopathological evaluation plays a key role in diagnosis within hospital-based biopsy services.
To describe the clinicopathological characteristics and anatomical distribution of oral malignant lesions and OPMDs in a tertiary care hospital.
This retrospective cross-sectional hospital-based case series included 1096 patients who underwent oral biopsy between 2020 and 2025. Only biopsy-confirmed malignant lesions and OPMDs were included, whereas benign oral lesions were excluded. Demographic, anatomical, biopsy, and histopathological data were analyzed using descriptive statistics and chi-square tests.
Males comprised 56.6% and females 43.4% of cases, with the highest lesion frequency in the 51-60-year age group (28.5%). Within this selected biopsy cohort, malignant lesions accounted for 64.8% and OPMDs for 35.2%. OSCC was the most common malignant lesion (44.9%), followed by verrucous carcinoma (23.2%). Leukoplakia with dysplasia (50.3%) and oral submucous fibrosis (27.2%) were the most frequent OPMDs. Buccal mucosa predominated in malignant lesions, whereas OPMDs were more common on the tongue.
This retrospective hospital-based case series provides descriptive clinicopathological insights into oral malignant lesions and OPMDs within a tertiary referral setting. Findings reflect a selected biopsy population.
PMID:
42522252
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.
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