Epidemiological characteristics of varicella and factors associated with breakthrough varicella among children aged 0-14 years in Jiangsu Province, China.

Authors

Mei Li, Yan Xu, Yurong Li, Qiang Chen, Chengmei Jia, Dongsheng Liu, Xiaozhe Song, Xue Yan Sha, Yuan Ren, Zhiguo Wang, Xiang Sun

Published in

Expert review of vaccines. Volume 25. Issue 1. Pages 2708202. Epub Jul 29, 2026.

Abstract

This study aimed to explore the epidemiological characteristics of varicella and breakthrough varicella (BV), as well as factors associated with the BV proportion during 2021-2024.
Data on varicella cases aged 0-14 years were extracted from the national surveillance system and linked to individual immunization records. Logistic and linear regression were adopted.
Among 162,844 cases, 34.3% were BV, and 10-14-year age group increased significantly from 24.7% in 2021 to 61.1% in 2024 (p < 0.001). During 2023-2024, older age groups showed lower BV proportion (5-9 years: OR = 0.49; 10-14 years: OR = 0.58; both p < 0.001), while the 10-14 years group showed higher BV proportion (OR = 1.08, p < 0.001) during 2021-2022. Autumn onset (OR = 1.14) and cases from central (OR = 1.39) and southern Jiangsu (OR = 2.31) were positively associated with BV proportion (all p < 0.001). The median breakthrough interval among one-dose recipients was 7.5 years, with 61.7% of cases occurring ≥6 years post-vaccination.
Varicella burden in Jiangsu is shifting to older children. Strengthening two-dose varicella vaccination and maintaining routine vaccination coverage in young children are crucial for varicella control.

PMID:
42522339
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.