Benzannulations of 2-(inden-1-ylidene)-malononitrile with ynones toward achieving ortho-aminofluorenyl methanone and fluorene[b]pyridine derivatives.

Authors

Yan Zhao, Wei He, Di Jing, Yin-Fu Zhang, Wen-Li Xu, Chuan-Bao Zhang, Yan-Bo Wang, Ji-Ya Fu

Published in

Organic & biomolecular chemistry. Jul 29, 2026. Epub Jul 29, 2026.

Abstract

A straightforward and scalable synthetic route to multisubstituted fluorenyl phenones has been developed via a metal-free [4 + 2] benzannulation of 2-(inden-1-ylidene)-malononitrile with ynones under mild conditions. This protocol provides direct and modular access to multisubstituted o-aminofluorenyl phenones and fluorene[b]pyridines with excellent functional group tolerance and a broad substrate scope.

PMID:
42522659
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.

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