DNA Vaccine Encoding the prM-E Polyprotein of the Tick-Borne Encephalitis Virus.

Authors

E V Tigeeva, V A Yakovlev, M B Borgoyakova, E V Starostina, K P Makarova, D I Vakhitov, E V Protopopova, V A Svyatchenko, V B Loktev, L A Kisakova, D N Kisakov, N B Rudometova, A P Rudometov, L I Karpenko

Published in

Bulletin of experimental biology and medicine. Jul 29, 2026. Epub Jul 29, 2026.

Abstract

We evaluated immunogenicity of the experimental DNA-vaccine construct pVAX-prM-E encoding the polyprotein prM-E of the tick-borne encephalitis virus (strain Sofjin). It was shown that pVAX-prM-E administered to mice using a needle-free jet injector induced the production of high levels of virus-neutralizing antibodies. The level of humoral response to pVAX-prM-E was comparable to that induced by administration of the commercial Tick-E-Vac vaccine. ELISpot analysis of the T-cell response showed that the obtained construct induces high levels of IFNγ in response to stimulation with a pool of specific E protein peptides. These findings indicate the high protective potential of this experimental DNA vaccine.

PMID:
42525345
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.

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