Bladder Perforation Following Transurethral Resection of Bladder Tumor With Immediate Intravesical Instillation of Epirubicin.

Authors

Junya Abe, Atsuro Sawada, Chie Onizuka, Takahiro Akioka, Naoko Nakai, Shimpei Kojima, Hiroki Sakamoto, Tomoya Horinouchi, Toshiyuki Kamoto

Published in

IJU case reports. Volume 9. Issue 5. Pages e70235. Epub Jul 28, 2026.

Abstract

Immediate postoperative intravesical chemotherapy following transurethral resection of bladder tumor (TURBT) is the standard procedure aimed at reducing recurrence.
An 84-year-old man was diagnosed with an incidental 13-mm intravesical tumor during screening for biochemical recurrence following radiation therapy for prostate cancer. Accordingly, he underwent TURBT, followed by immediate postoperative intravesical chemotherapy with epirubicin. On postoperative day 2, he developed abdominal pain. Computed tomography demonstrated bladder perforation accompanied by retroperitoneal free air. He was diagnosed with extraperitoneal bladder perforation and thus managed with urethral catheterization; however, conservative treatment failed. Consequently, surgical repair with debridement was performed. Pale whitish granulation tissue was observed within the perivesical fat, suggesting epirubicin extravasation. Subsequently, cystography performed 28 days after bladder repair showed no contrast extravasation.
Surgical treatment should be considered as a potential treatment option for patients with suspected chemotherapy extravasation in whom conservative management is unsuccessful.

PMID:
42524631
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.