Sleeve Gastrectomy Effect on Structural and Functional Myocardium Characteristics and Trpc3, Trpc6, Tgfb1, and Atp2a2 Gene Expression in Rats with Post-Infarction Heart Failure.

Authors

V I Pan, O V Kornyushin, T A Lelyavina, D O Sonin, A S Polozov, Yu V Cheburkin, P A Kapustina, E A Zaytseva, Ya G Toropova, K V Derkach, A O Shpakov, M M Galagudza

Published in

Bulletin of experimental biology and medicine. Jul 29, 2026. Epub Jul 29, 2026.

Abstract

A positive effect of sleeve gastrectomy on the structural and functional characteristics of the left ventricular myocardium in rats with normal body weight and post-infarction CHF was demonstrated. Sleeve gastrectomy attenuated the upregulated myocardial expression of the Trpc6 and Tgfb1 genes involved in the pathogenesis of myocardial infarction. These findings attest to a reduction of the negative effects of post-infarction cardiac remodeling.

PMID:
42525343
Bibliographic data and abstract were imported from PubMed on 29 Jul 2026.

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