Molecular grappling: the complex interplay involving human herpesviruses, small ubiquitin-like modifier (SUMO), and the host immune system.

Authors

Sairam Dasika, Janna M Bigalke

Published in

Current opinion in virology. Volume 77. Pages 101570. Jul 29, 2026. Epub Jul 29, 2026.

Abstract

SUMOylation regulates critical cellular processes, including DNA repair, transcription, and immune responses. Human herpesviruses (HHVs) have evolved mechanisms to hijack the SUMO pathway, promoting viral replication, immune evasion, and establishment of latency. This review explores how HHVs manipulate the host SUMOylation machinery, detailing key viral proteins and their effects, as well as antiviral defense mechanisms.

PMID:
42526104
Bibliographic data and abstract were imported from PubMed on 30 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.