SGLT2 Inhibitors as Modulators of Mitochondrial Ion Transport and ER-Mitochondria Crosstalk in Diabetic Cardiomyopathy.

Authors

Jessa Flores, Maria Victoria Faith Garcia, Prycelline Abedejos, Jed Allyn Hernandez, Trong Kha Pham, Hyoung Kyu Kim, Jubert Marquez, Jin Han

Published in

American journal of physiology. Cell physiology. Jul 29, 2026. Epub Jul 29, 2026.

Abstract

Diabetic cardiomyopathy (DCM) is a major complication of type 2 diabetes mellitus and a leading contributor to heart failure. A central feature of DCM is the disruption of mitochondrial bioenergetics and calcium homeostasis, processes that are tightly regulated through mitochondria-associated endoplasmic reticulum membranes (MAMs). These ER-mitochondria contact sites coordinate mitochondrial ion transport systems, including the mitochondrial calcium uniporter (MCU), Na⁺/Ca²⁺ exchanger (NCLX), and potassium channels, which collectively govern mitochondrial metabolism, redox balance, and cell survival.

PMID:
42526021
Bibliographic data and abstract were imported from PubMed on 30 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.