Abstract: Solitary Colonic Ganglioneuroma Identified on Screening Colonoscopy: A Case Report.

Authors

Grace Geffre, Brandon Rosell, Ashwyna Sunassee, Ahmed T Kurdi

Published in

South Dakota medicine : the journal of the South Dakota State Medical Association. Volume 79. Issue suppl 5. Pages s29.

Abstract

Ganglioneuromas are rare benign tumors derived from neural crest cells of the enteric nervous system. Stemming from the sympathetic nervous system, they are mostly encountered in the abdomen and rarely in the gastrointestinal tract. Polypoid ganglioneuromas are usually solitary. Ganglioneuromatous polyposis can be associated with systemic and familial syndromes such as Neurofibromatosis type I, Cowden syndrome, and Multiple Endocrine Neoplasia type 2B.
We report the case of an asymptomatic 60-year-old female who was incidentally found to have a 4 mm sessile sigmoid polypoid lesion on a routine screening colonoscopy. The lesion was resected with a cold snare. Other diminutive polyps were similarly resected and consistent with tubular adenomas. Histopathology of the lesion confirmed a colonic ganglioneuroma. Unique features included expansion of the lamina propria by edema and a poorly circumscribed population of eosinophilic spindle cells with curved and tapered nuclei without atypia (H&E x40). Higher magnification (H&E x200) showed larger ganglion cells admixed with abundant amphophilic cytoplasm, round nuclei, and prominent eosinophilic nucleoli. Immunohistochemical staining reveals the spindle schwannian cells and larger ganglion cells are positive for S100 and SOX10 and negative for smooth muscle actin (SMA), CD117 (KIT), and DOG-1 (x40).
Solitary polypoid ganglioneuromas of the colon are rare benign tumors with unique histopathologic features that do not tend to recur with adequate resection. Notably for these tumors, polyposis can be associated with systemic and familial syndromes. Till present, there are no recommendations on surveillance colonoscopy for solitary ganglioneuromas. Given tubular adenomas were concurrently resected, a repeat evaluation in 5 years was recommended to this patient.

PMID:
42525994
Bibliographic data and abstract were imported from PubMed on 30 Jul 2026.

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