Cancer neuroscience: Mechanisms to medicine.

Authors

Lilach Pasvolsky, Gregory H Jones, Yen Vu, Frank Winkler, Moran Amit

Published in

Science translational medicine. Volume 18. Issue 860. Pages eaeh1718. Jul 29, 2026. Epub Jul 29, 2026.

Abstract

The nervous system is now recognized as an enabling hallmark of cancer biology. Neural inputs drive tumor growth in both central nervous system tumors and extracranial tumors through different mechanisms, including synaptic signaling, adrenergic regulation, perineural invasion, neuropeptides, immune remodeling, and bioelectric mechanisms. These insights have facilitated repurposing of neuroactive agents that are now in clinical trials as adjuncts to standard cancer therapy. The central translational challenge now is how to match the right neural circuit to the right patient and to pair appropriate neuromodulators with immunotherapy in combinations designed to restore, rather than merely supplement, antitumor immunity.

PMID:
42525788
Bibliographic data and abstract were imported from PubMed on 30 Jul 2026.

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