Authors
Lucas de Lima Nogueira, Lucas Romão Alves Vasconcelos, Cristiane Cunha Frota, Regis Bernardo Brandim Gomes, Clarissa Romero Teixeira, Shirlene Telmos Silva de Lima, Francisco Gustavo Silveira Correia, Paulo Rafael Cardoso de Sousa, Rafael Mota Ferreira, Francisco Marto Leal Pinheiro Junior, Adriano Ferreira Martins, Carlos Sanhueza-Sanzana, Ítalo Wesley Oliveira Aguiar, Carl Kendall, Ligia Regina Franco Sansigolo Kerr
Published in
Ciencia & saude coletiva. Volume 31. Issue 6. Pages e08432023. Epub May 16, 2025.
Abstract
The kinetics of IgG-specific antibody responses against chikungunya virus (CHIKV) is poorly understood. A total of 559 paired serum samples were collected at baseline and at first follow-up in a cohort of women aged 15-39 years from endemic areas of Fortaleza, Ceará State, following the major 2017 outbreak from February 2018 to August 2019. To estimate longitudinal seroprevalence, combining antibody markers (anti-CHIKV IgM and IgG) were screened by using enzyme-linked immunosorbent assays. We found an overall seroprevalence of 34% (190/559; 95%CI, 30.2-38.0) and 31.3% (175/559; 95%CI, 27.6-35.3) at baseline and first follow-up, respectively. Also, the distribution of seroprevalence did not differ significantly by age group [15-24 years, 35.4% (92/260); 25-39 years, 32.8% (98/299)]. Additionally, we found that median IgG level decreased over time across all age groups, and independent of prior history of symptomatic infection. We also observed four cases of seroreversion. Our findings provided valuable information regarding the decline of anti-CHIKV IgG levels in a post-epidemic scenario, highlighting the importance of serological surveillance to better understand the kinetics of antibody responses and to characterize epidemic risk.
PMID:
42525035
Bibliographic data and abstract were imported from PubMed on 30 Jul 2026.
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