Leukemic presentation of ALK-positive anaplastic large cell lymphoma in an adult patient with hemophagocytic lymphohistiocytosis.

Authors

Mark Oliver, Jenny Byrd, Eduard Matkovic

Published in

Journal of hematopathology. Volume 19. Issue 1. Jul 30, 2026. Epub Jul 30, 2026.

Abstract

Systemic ALK + anaplastic large cell lymphoma (ALCL) is a CD30-positive T cell neoplasm that commonly affects lymph nodes with frequent involvement of extranodal sites. A leukemic phase with peripheral blood involvement is extremely rare, and therefore, recognition of this uncommon phenomenon is crucial to avoid misdiagnosis and delayed treatment. We report a case of a previously healthy adult patient who presented with peripheralizing ALK-positive ALCL accompanied by hemophagocytic lymphohistiocytosis (HLH). Comprehensive ancillary studies were essential for establishing the diagnosis and determining blood involvement.

PMID:
42530775
Bibliographic data and abstract were imported from PubMed on 30 Jul 2026.

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