Giving structure meaning: Modelling the cellular synapse of excitation-contraction coupling in skeletal muscle.

Authors

Werner Melzer

Published in

The Journal of general physiology. Volume 158. Issue 5. Sep 07, 2026. Epub Jul 30, 2026.

Abstract

Ca2+-ions, stored in a muscle fiber's SR, are rapidly released during electrical activity of the cell membrane to activate force, a process termed excitation-contraction coupling (EC coupling). In this process, the narrow junctional gap between the membrane of the transverse tubules (TT), which conduct the surface action potential into the fiber volume, and the membrane of the terminal cisternae of the SR has to be bridged. The publication by Rios and Pizarro in this journal issue (https://doi.org/10.1085/jgp.202613968) offers a model inspired by structural data that comprehensively explains many aspects of the coupling process.

PMID:
42530491
Bibliographic data and abstract were imported from PubMed on 30 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.