Synthesis, In Vitro Antimicrobial Assessment, and Molecular Docking Investigations of Some Derived Compounds From Porphyrins.

Authors

Mondher Dhifet, Bilel Bouzayani, Hayet Edziri, Marwa Melliti, Mabrouk Horchani, Ridha Ben Salem, Habib Nasri

Published in

Journal of fluorescence. Jul 30, 2026. Epub Jul 30, 2026.

Abstract

Porphyrins and their derivatives constitute a class of macrocyclic compounds of major interest in chemistry, biology, and medicine due to their remarkable structural and functional properties. In this work, we describe the synthesis of three substituted porphyrin derivatives obtained using classical and optimized methods. Spectroscopic characterization was performed using UV-Visible, infrared (IR), and nuclear magnetic resonance (NMR) spectroscopy, which confirmed the molecular structures of the porphyrin systems. In addition, a comparative study of the biological activity of these derivatives was carried out, highlighting their potential in several fields such as antimicrobial activity (antibacterial and antifungal) as well as antibiofilm activity. In addition, molecular docking studies against the targeted receptors (pdb: 3u2d, pdb: 1kzn, and pdb: 6y98) were performed. These investigations provided critical information about the binding mechanisms of the synthesized porphyrin derivatives towards selected receptors. Significant results were obtained, especially with compound 3b.

PMID:
42530758
Bibliographic data and abstract were imported from PubMed on 30 Jul 2026.

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