Bile salt hydrolase-active bifidobacterium animalis improves sarcopenia via the gut microbiota-bile acid-FXR-FGF15 axis and its functional fermented milk preparation.

Authors

Qinglian Hua, Qiyu Ma, Huaxi Yi, Lanwei Zhang, Xi Liang, Zhe Zhang

Published in

Food chemistry. Volume 525. Issue Pt 3. Pages 150594. Jul 28, 2026. Epub Jul 28, 2026.

Abstract

Sarcopenia is a major global health challenge associated with aging, and effective pharmacological treatments are lacking. This study investigated how bile salt hydrolase (BSH)-active probiotics alleviate sarcopenia through bile acid deconjugation and remodeling, activating the intestinal FXR-FGF15/19 signaling pathway, and explored their application in functional dairy products. Three high-BSH strains-Lactiplantibacillus plantarum H-87, Bifidobacterium animalis F1-7, and F1-3-2-were identified, among which F1-7 and F1-3-2 showed superior efficacy in a dexamethasone-induced sarcopenia model. These strains improved muscle mass, morphology (including increased muscle fiber cross-sectional area and improved histological integrity), and performance by modulating gut microbiota, optimizing bile acid composition, and enhancing ileal FXR-FGF15 signaling to activate the muscle FGFR4/KLB pathway and inhibit protein degradation. Furthermore, fermented milk produced with F1-7 and F1-3-2 met quality standards and exhibited improved sensory properties. This study provides a mechanistic basis for developing probiotic dairy products and sustainable nutritional strategies for sarcopenia.

PMID:
42531634
Bibliographic data and abstract were imported from PubMed on 31 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.