Cell-autonomous immunity as an integrated immune network against bacterial and viral pathogens.

Authors

Lorena Martín-González, Bruno Ramos, Yizhou Huang, Teresa Thurston, Greg Towers, Damián Lobato-Márquez

Published in

Nature microbiology. Volume 11. Issue 8. Pages 2098-2111. Epub Jul 30, 2026.

Abstract

All cells possess a diverse array of cell-autonomous immune responses that can detect and restrict infections by intracellular pathogens. These intrinsic responses (both passive and active) enable individual cells to autonomously block bacterial and viral invasion and replication. Epithelial and endothelial cells act as a first line of defence, coordinating immune responses that preserve host barrier integrity. These cells can also mount specialized innate immune responses (many of which are triggered by antimicrobial cytokines, such as interferons) to limit the replication and motility of intracellular bacteria and viruses. To counteract these, bacteria and viruses have developed strategies to avoid or antagonize host defences, driving an evolutionary arms race that shapes every aspect of host-pathogen interactions. This Review provides an overview of current knowledge of cell-autonomous immunity against bacteria and viruses. We emphasize the factors underpinning host cell surveillance and restriction of cytosolic pathogens and mechanisms of immune evasion deployed by the invading microorganism.

PMID:
42533066
Bibliographic data and abstract were imported from PubMed on 31 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.