Combined phage therapy and faecal microbiota transplantation to treat recurrent urinary tract infection: a case series.

Authors

Shawna McCallin, Annika Y Classen, Simone C Lieberknecht-Jouy, Fatih Abdula, Sarah Dugas, Oliver Gross, Hendrik Koliwer-Brandl, Swenja Lassen, Jens Scheidegger, Matthew Dunne, Andre Kahles, Jonas Eigler, Fedja Farowski, Paul G Higgins, Sonja Milek, Oksana Chemych, Jiemin Du, Martin J Loessner, Thomas M Kessler, Maria J G T Vehreschild, Lorenz Leitner, Lena M Biehl

Published in

Nature microbiology. Volume 11. Issue 8. Pages 2112-2118. Epub Jul 30, 2026.

Abstract

Recurrent urinary tract infections are recalcitrant and difficult-to-treat bacterial infections that primarily affect women. Here we combine phage therapy with faecal microbiota transplantation to decolonize the urinary and intestinal reservoirs of patients with recurrent urinary tract infections. Three women received oral and intravesical phage therapy for 8 days, and two underwent subsequent faecal microbiota transplantation. Treatments were well tolerated, and although Escherichia coli was detected in follow-up samples, patients experienced none or fewer and less severe episodes of urinary tract infection 24 months post-treatment.

PMID:
42533067
Bibliographic data and abstract were imported from PubMed on 31 Jul 2026.

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