PET/CT false-negative angioimmunoblastic T-cell lymphoma: a case report and literature review.

Authors

Yiling Bai, Yisong Xiong, Hengning Lian, Guangqing Shi, Yue Teng, Lijie Ma

Published in

Frontiers in oncology. Volume 16. Pages 1884224. Epub Jul 16, 2026.

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is a peripheral T-cell lymphoma characterized by heterogeneous clinical and immunologic manifestations. We report a 65-year-old female whose morphologically abnormal superficial lymph nodes were fluoro-D-glucose (FDG)-negative on positron emission tomography/computed tomography (PET/CT), while deep mediastinal and hilar nodes were hypermetabolic. Initial biopsies of FDG-avid sites were non-diagnostic. Definitive diagnosis was ultimately achieved via excisional biopsy of a superficial node. This case underscores that AITL may exhibit PET/CT false-negativity, highlighting the need for integrating clinical, laboratory, flow cytometry, and histopathologic data to avoid diagnostic delays.

PMID:
42534748
Bibliographic data and abstract were imported from PubMed on 31 Jul 2026.

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