Progressive Cerebellar Dysfunction, Pituitary Insufficiency, and Severe Skeletal Fragility in Adult Survivorship of Childhood Multisystem Langerhans Cell Histiocytosis: A Case Report.

Authors

Suhaib Alnahar, Alaa Senjab, Sara Gharib, Zena Gharib, Lama Hadid

Published in

Clinical case reports. Volume 14. Issue 8. Pages e73261. Epub Jul 29, 2026.

Abstract

Childhood-onset multisystem Langerhans cell histiocytosis can lead to delayed adult morbidity involving the neurologic, hypothalamic-pituitary, and skeletal systems. Progressive cerebellar dysfunction, chronic pituitary insufficiency, and severe skeletal fragility may emerge years after apparent disease control, underscoring the need for prolonged multidisciplinary follow-up.

PMID:
42534434
Bibliographic data and abstract were imported from PubMed on 31 Jul 2026.

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