Recent trends of organic synthesis through cobalt metal-based catalysis: a review.

Authors

Sehrish Sewyra, Muhammad Zubair, Saima Bibi, Nighat Nawaz, Rehana Riaz, Faiz Ahmed

Published in

RSC advances. Jul 30, 2026. Epub Jul 30, 2026.

Abstract

Over the last three decades, transition-metal-catalysed organic transformations have been shown to be extremely important in organic synthesis. Cobalt, a first-row transition metal, has gained prominence due to its low toxicity, cost-effectiveness, and unique reactivity profiles, making it an attractive alternative to more precious metals traditionally used in catalysis. This review highlights the recent progress in the synthesis of biologically important organic compounds facilitated by cobalt metal-based catalysis, underscoring the versatility, and efficiency of these methodologies. In this review various cobalt-catalysed reactions like cycloaddition, cross coupling, multicomponent reaction, hydrogenation, reduction, hydroboration, amidation, annulation, isomerization and carbonylation reactions have been discussed since 2020, in which the products obtained have high yields with excellent enantioselectivities (ee). Future research in this area is poised to further expand the scope of cobalt-catalysed reactions, opening new avenues for the efficient and sustainable synthesis of biologically important compounds.

PMID:
42534540
Bibliographic data and abstract were imported from PubMed on 31 Jul 2026.

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