Taming the reactive intermediates: the nazarov cyclization as a programmable platform.

Authors

Yunfei Cheng, Ye Yuan, Qun Sun

Published in

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. Jul 31, 2026. Epub Jul 31, 2026.

Abstract

The Nazarov cyclization has evolved from a traditional acid-driven electrocyclization into a flexible synthetic platform. This review summarizes its transformation through a strategic framework centered on three control points: initiation, diverting, and stereochemistry. Modern initiation strategies (substrate pre‑activation, cooperative catalysis, photochemical excitation) replace harsh acids; diverting the oxyallyl cation delivers complex structures via intra‑ or intermolecular trapping; and stereochemical control ranges from chiral auxiliaries to novel catalytic systems. Key advances are illustrated through natural product syntheses.

PMID:
42536108
Bibliographic data and abstract were imported from PubMed on 31 Jul 2026.

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