Evidence summary of nursing care of arterial drug administration and catheter management for HAIC in hepatocellular carcinoma.

Authors

Zuxin Shi, Linqiu Han, Tian He, Mingyan Shen

Published in

Medicine. Volume 105. Issue 31. Pages e49992. Jul 31, 2026.

Abstract

This study aimed to summarize and grade the existing evidence on continuous hepatic artery infusion chemotherapy (HAIC) arterial drug administration and catheter care, providing evidence-based guidance for clinical nursing decisions.
Using the "6S" pyramid model, We searched 10 electronic resources (UpToDate, Joanna Briggs Institute [JBI], Cochrane Library, Web of Science, Embase, PubMed, EBSCOhost Research Platform, China National Knowledge Infrastructure, Wanfang, and SinoMed) and 5 professional organization websites (National Comprehensive Cancer Network, the American Society of Clinical Oncology, the Japan Society of Clinical Oncology, the Oncology Nursing Society, and the Multinational Association of Supportive Care in Cancer/European Society for Medical Oncology) from inception to March 31, 2024. Quality appraisal tools were selected by evidence type: Appraisal of Guidelines for Research and Evaluation II for guidelines, JBI critical appraisal tools for systematic reviews/meta-analyses and JBI standards for expert consensus, and the Critical Appraisal for Summaries of Evidence tool for evidence summaries. Evidence was graded using the JBI levels of evidence (2014).
We identified 769 records and included 12 publications (1 guideline, 2 systematic reviews, 4 meta-analyses, 2 evidence summaries, and 3 expert consensus documents). A total of 36 evidence statements were organized into 4 domains: HAIC puncture care (8), medication care (15), complication prevention and management (10), and catheter removal care (3). Evidence levels ranged from 1b to 5b.
This evidence summary offers clear, graded recommendations to guide continuous arterial drug administration and catheter care in HAIC. The evidence can be used to develop or update local protocols and to support bedside decisions on HAIC drug delivery and catheter management. Implementation should be tailored to local healthcare settings by considering workflow, device availability, staffing capacity, and patient risk profiles to optimize safety and feasibility.

PMID:
42536554
Bibliographic data and abstract were imported from PubMed on 01 Aug 2026.

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