Remotely delivered parents helping parents for youth nicotine vaping cessation recruited via electronic health records: Protocol for a feasibility randomized controlled trial.

Authors

Tzeyu L Michaud, Sara Reyes, Nicholas Guenzel, Paula Guastello, Ellen Kerns, Meredith Berkman, Dorian Fuhrman, Lori Skrobola, Caroline Joyce, Emara Nabi, Jonathan P Winickoff, Hongying Daisy Dai

Published in

Contemporary clinical trials. Pages 108416. Jul 31, 2026. Epub Jul 31, 2026.

Abstract

Quitting vaping continues to be challenging for adolescents, with most reporting unsuccessful attempts to quit. The existing evidence base lacks interventions that combine parental support, peer-to-peer coaching for parents, and developmentally appropriate components for adolescents.
This study aims to outline the study design and protocol of a pilot trial examining the feasibility and preliminary effectiveness of a multicomponent vaping cessation intervention, focusing on parent-to-parent coaching support, designed for adolescents aged 15-18 years.
This study applies a two-arm, parallel-group pilot randomized controlled trial designed to assess the feasibility, acceptability, and preliminary effectiveness of the Parents Helping Parents for Youth Vaping Cessation (PhP-VX) intervention with a 6-month study duration. A total of 100 parent-adolescent dyads will be randomized in a 1:1 ratio to either the PhP-VX intervention arm or the waitlist control arm. The 12-week PhP-VX intervention includes one-on-one coaching sessions for parents delivered by trained parent coaches and supplementary vaping cessation e-learning modules. Primary outcomes include predefined benchmarks for acceptability, defined as a mean satisfaction score of ≥3.5 on a 5-point scale and ≥ 75% of parent participants reporting that they would recommend the program. Feasibility outcomes include reach, recruitment, engagement, and retention. Preliminary effectiveness outcome includes self-reported 7-day point prevalence abstinence at Months 1, 3, and 6. Recruitment for the study commenced in March 2026 and is anticipated to conclude in June 2027.
Findings from this pilot trial will inform the development of future family-based youth vaping cessation interventions and guide refinement of the current protocol for a large-scale trial.
ClinicalTrials.gov NCT07207850.

PMID:
42537925
Bibliographic data and abstract were imported from PubMed on 01 Aug 2026.

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