Authors
Tonino Alonzi, Assunta Navarra, Razaq Durodoye, Jacquelaine Bartlett, Anna Rosa Garbuglia, Daniela Lapa, Valentina Vanini, Gilda Cuzzi, Andrea Capri, Annapaola Santoro, Vincenzo Puro, Enrico Girardi, Gina Gualano, Fabrizio Palmieri, Gian Maria Fimia, Mauro Piacentini, Anurag Verma, Scott M Williams, Giorgio Sirugo, Delia Goletti
Published in
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. Pages 109024. Jul 31, 2026. Epub Jul 31, 2026.
Abstract
Autophagy is a key host defense mechanism against Mycobacterium tuberculosis (Mtb). The autophagy‑regulating gene, immunity-related GTPase M (IRGM), may influence tuberculosis (TB) susceptibility.
To investigate whether two IRGM single-nucleotide polymorphisms (SNP), rs4958847 and rs72553867, are associated with TB disease and/or TB infection (TBI).
An unmatched case-control study was conducted at the National Institute of Infectious Diseases L. Spallanzani-IRCCS, Italy. Logistic regression analyses evaluated the effects of individual SNPs and their diplotypes on TB status.
Among 709 participants enrolled in Italy with diverse European ancestries, 644 individuals with complete data were included. Individual SNP analysis of 194 TB patients, 194 TBI individuals, and 256 TB-free controls revealed no significant associations with TB status. However, diplotype analysis identified an association between the rs4958847-rs72553867 GG-AC vs GG-CC diplotype with TB diseases with respect to TB-free group (OR=2.56, 95% CI:1.18-5.56).
Although the individual IRGM variants were not associated with TB, combined diplotype analysis indicated a potential role for IRGM-mediated autophagy in TB disease within European populations.
PMID:
42537778
Bibliographic data and abstract were imported from PubMed on 01 Aug 2026.
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