Authors
Victoria R Yarmey, Daisy Aguilar Aguilar, Adriana San-Miguel
Published in
bioRxiv : the preprint server for biology. Jul 25, 2026. Epub Jul 25, 2026.
Abstract
Chemosensory signaling is crucial for organisms to respond to their environment and dysfunctions in these complex pathways have been implicated in diseases such as neurological disorders. The nematode C. elegans is a useful tool for studying chemosensation as it offers a fully-mapped nervous system with relatively simple chemosensory circuits. One of the most common methods to quantify chemosensory function in worms is through chemotaxis assays, which require extensive time and manual effort. In this work, we sought to capture novel chemosensory metrics and increase the throughput of these assays by combining rapid image acquisition with bioinformatics processing. In doing so, we have developed a Technique for Automating chemotaXis Investigations using Simple-Capture Approaches in Nematodes (TAXISCAN), a rapid acquisition platform that can be used to study natural chemosensory behavior as well as to characterize behavioral and locomotion phenotypes in half the time of standard assays.
The TAXISCAN platform provides a rapid, accurate, and inexpensive means of conducting unbiased chemotaxis assays in C. elegans In addition to the Chemotaxis Index (CI), the TAXISCAN platform can quantify behavioral metrics such as movement speed, distance travelled, and dispersion patternsWe successfully use TAXISCAN to discriminate behavioral phenotypes in neurosensory mutants.
PMID:
42539017
Bibliographic data and abstract were imported from PubMed on 01 Aug 2026.
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