Noise Optimization of Basic Signal Component Extraction for Cryogenic and On-Scalp Magnetoencephalography (MEG).

Authors

Alexandria McPherson, Sepp Sanchirico, Albert Xu, Eric Larson, Milena Kaestner, William Turner, Laura Gwilliams, Samu Taulu

Published in

bioRxiv : the preprint server for biology. Jul 26, 2026. Epub Jul 26, 2026.

Abstract

Magnetoencephalography (MEG) measures human neural activity non-invasively with spatio-temporal precision, and has been foundational in enabling impactful discoveries in cognitive neuroscience. New on-scalp MEG sensor technologies, such as OPM-MEG, offer the opportunity to capture more information about the neuronal magnetic fields with higher sensitivity to more complex, higher order spatial components, leading to improved source localization. The accuracy of MEG and OPM-MEG source localization relies on data preprocessing techniques to isolate the neuronal fields from other magnetic and biomagnetic sources through signal space separation, rejection, and suppression methods. Current preprocessing methods risk rejecting brain signals of interest, or can spread sensor noise artifacts unknowingly. Here we propose a novel preprocessing method for MEG, and test the extent to which it overcomes limitations of prior methods. Specifically, we derive, apply, and assess a novel signal space separation (SSS) method with Foster's inverse, a weighted matrix inversion protocol that can utilize information about the MEG sensor noise and artifacts to reconstruct neuronal activity. With simulations, phantom head cryogenic MEG recordings, and subject recordings with two OPM-MEG systems, we show that Foster's inverse with SSS offers a more robust and stable reconstruction of the neuronal magnetic fields, especially in the face of sensor noise and artifacts. As the field of cognitive neuroscience continues to embrace MEG and OPM-MEG, Foster's inverse with SSS offers a robust and powerful data preprocessing technique for reducing noise and improving source localization of the underlying neuronal currents.

PMID:
42539285
Bibliographic data and abstract were imported from PubMed on 01 Aug 2026.

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