Development and validation of a multiparametric MRI habitat radiomics nomogram for predicting early complete response to induction chemoimmunotherapy in locally advanced nasopharyngeal carcinoma.

Authors

Bifa Zhu, Kaihua Chen, Zuguang Wen, Liru Zhu, Ling Li, Xiaodong Zhu

Published in

European journal of radiology. Volume 204. Pages 113112. Jul 28, 2026. Epub Jul 28, 2026.

Abstract

To develop and externally validate a pretreatment multiparametric MRI-based habitat radiomics nomogram for predicting early complete response (CR) after induction chemoimmunotherapy in locally advanced nasopharyngeal carcinoma (LANPC).
This two-center retrospective study included 435 patients with LANPC treated with induction chemoimmunotherapy between January 2021 and January 2025. Patients from Guangxi Medical University Cancer Hospital (GXMUCH) were divided into training (n = 195) and internal validation (n = 49) cohorts, and patients from the First Affiliated Hospital of Guangxi Medical University (FAH-GXMU) formed an independent external test cohort (n = 191). Pretreatment T1-weighted, fat-suppressed T2-weighted, and contrast-enhanced T1-weighted images were analyzed. Voxel-wise multiparametric MRI features were clustered to generate habitat subregions. Conventional radiomics, habitat radiomics, combined radiomics, and radiomics nomogram models were developed and evaluated using AUC, calibration, decision curve analysis, and DeLong test.
Early CR was achieved in 51, 11, and 56 patients in the three cohorts, respectively. Habitat radiomics outperformed conventional whole-tumor radiomics, with the external test AUC increasing from 0.735 to 0.821. The combined radiomics model and radiomics nomogram achieved external test AUCs of 0.827 and 0.840, respectively. The nomogram yielded the highest numerical AUCs in the three cohorts (0.961, 0.888, and 0.840, respectively).
Pretreatment multiparametric MRI-based habitat radiomics provided additional predictive information beyond conventional whole-tumor radiomics for early CR prediction after induction chemoimmunotherapy in LANPC. The radiomics nomogram may serve as a clinically interpretable tool for individualized response stratification, although prospective multicenter validation is warranted.

PMID:
42541996
Bibliographic data and abstract were imported from PubMed on 02 Aug 2026.

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