Cytotoxic sesquiterpene alkaloids isolated from Nuphar pumila (Timm) de Candolle.

Authors

Bo Ma, Yutong Li, Shengdan Mi, Jiang Li, Jing Jin, Guozhu Su, Yong Li

Published in

Fitoterapia. Pages 107413. Aug 01, 2026. Epub Aug 01, 2026.

Abstract

Five undescribed nupharidines, namely amidonupumones A-C (1-3), amidonupumol A (4), and dinupharolutine (7), along with twelve known analogues (5, 6, 8-17) were isolated from Nuphar pumila. Their structures were elucidated by extensive spectroscopic data, ECD, NMR calculations, and X-ray diffraction. Among them, compounds 1-4 represent the first alkaloids containing an amide structure isolated from N. pumila. In vitro bioassays revealed that compounds 7 and 11 exhibited broad-spectrum cytotoxic activity at a concentration of 40 μM.

PMID:
42542302
Bibliographic data and abstract were imported from PubMed on 02 Aug 2026.

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