Antimicrobial aromatic Butenolides and anthraquinone derivative produced in cocultures of Cordyceps militaris ZYb8 and Malbranchea ostraviensis SS1.

Authors

Hongyan Yang, Qian Luo, Jiaqian Yang, Yongcai Zhang, Xiaomei Zhang

Published in

Fitoterapia. Pages 107417. Aug 02, 2026. Epub Aug 02, 2026.

Abstract

Integrated with LC-MS/MS-based molecular networking analysis, eight previously undescribed compounds-eutypoid G-K (1-5), gotjawalides A-B (6-7), and ocauxarthrol B (8)-along with 11 known natural products (9-19) were isolated from the coculture of Cordyceps militaris ZYb8 and Malbranchea ostraviensis SS1. The structures of those previously undescribed compounds (1-8) were elucidated through comprehensive spectroscopic data analyses, including NMR, HRESIMS, UV, and IR. The absolute configurations of compounds 6-8 were assigned by comparing experimental electronic circular dichroism (ECD) spectra with theoretically calculated spectra. Antimicrobial assays revealed that compounds 1-13, 15-16, and 19 exhibited weak to moderate selective antibacterial activities against S. aureus, B. subtilis, S. pneumoniae, and K. pneumoniae with MIC values ranging from 4 to 128 μg/mL.

PMID:
42543088
Bibliographic data and abstract were imported from PubMed on 03 Aug 2026.

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