Rare Fusions, Real Targets: Ultraprecision Oncology in Lung Cancer.

Authors

Xiuning Le, Jürgen Wolf

Published in

Cancer discovery. Volume 16. Issue 8. Pages 1480-1482. Aug 03, 2026.

Abstract

Beyond established rare fusions, such as ALK and ROS1, emerging ultrarare fusions involving receptor tyrosine kinases or their ligands, including EGFR-SHC1, further guide us to uncover novel mechanisms of oncogenic activation and corresponding treatment strategies. Collectively, rare and ultrarare genomic events are driving precision oncology toward an increasingly individualized era of "ultraprecision" cancer therapy. See related article by Zheng et al., p. 1573.

PMID:
42544043
Bibliographic data and abstract were imported from PubMed on 03 Aug 2026.

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