Processing Speed and Verbal Learning Ability as Predictors of Assessor-Rated and Ecological Momentary Assessment Self-Reported Functioning: Findings from AMP SCZ.

Authors

Danielle N Pratt, Kathryn E Lewandowski, Hannah Hacker, Lana Kambeitz-Ilankovic, Walid Yassin, Jai Shah, Kelly Allott, William S Stone, Jean Addington, Alison R Yung, Trevor F Williams, Henry R Cowan, Siyan He, Jason Schiffman, Ricardo E Carrión, John Torous, Paolo Fusar-Poli, Martin Lepage, Sung-Wan Kim, Swapna Verma, Merete Nordentoft, Louise B Glenthøj, Stefan Smesny, Philippe Conus, Matthew R Broome, Christy L M Hui, Fred W Sabb, Diana O Perkins, Albert R Powers, Monica E Calkins, Daniel H Wolf, Cheryl M Corcoran, Leslie E Horton, Lauren M Ellman, Gregory P Strauss, Daniel Mamah, Godfrey D Pearlson, Jimmy Choi, Minah Kim, Joseph Kambeitz, Pablo A Gaspar, Daniel H Mathalon, Kristin S Cadenhead, Jesus Perez, Celso Arango, Nikolaos Koutsouleris, Steven Silverstein, Nicholas J K Breitborde, Sylvain Bouix, Justin T Baker, Tina Kapur, Ofer Pasternak, Rene S Kahn, Guillermo Cecchi, Michael J Coleman, John M Kane, Patrick D McGorry, Carrie E Bearden, Barnaby Nelson, Martha E Shenton, Scott W Woods, Vijay A Mittal

Published in

Schizophrenia bulletin. Volume 52. Issue 4. Jul 03, 2026.

Abstract

Processing speed and verbal learning are linked to functioning in people at clinical high-risk for psychosis (CHR-P). However, a clear understanding of these relationships has been limited by the use of single-value assessor ratings of functioning and limited incorporation of self-report and longitudinal functional assessments. This study aims to examine the effect of processing speed and verbal learning on longitudinal assessor-rated and self-reported functioning.
Individuals at CHR-P (n = 1282) and community controls (n = 425) who participated in Accelerating Medicines Partnership-Schizophrenia were examined. Processing speed and verbal learning abilities were ascertained using the Penn Computerized Neurocognitive Battery. Assessor-rated functioning was measured using the Global Functioning Scales. Self-reported functioning was collected using Ecological Momentary Assessment. Analyses were linear models and mixed-effects models.
Both processing speed and verbal learning were associated with assessor-rated functioning at baseline and through 2 months (Ps < 0.001). Processing speed abilities predicted changes in self-reported ability to function (P = .036), motivation (P = .040), and concentration (P = .020) over time. Verbal learning abilities predicted changes in self-reported loneliness (P = .044) over time. Processing speed and verbal learning were associated with assessor-rated and self-reported functioning over and above estimated intelligence quotient and positive symptoms.
Processing speed and verbal learning are important predictors of short-term longitudinal functioning, and may be important targets for early recognition and mitigation of psychosis risk.

PMID:
42544492
Bibliographic data and abstract were imported from PubMed on 03 Aug 2026.

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