Iodine Avid Muscle Metastases Mimicking Skeletal Lesions on Whole-Body Iodine Scan in Poorly Differentiated Thyroid Carcinoma -SPECT/CT to the Rescue.

Authors

Amisha Jamwal, Raza A Mahdi, Swayamjeet Satapathy, Piyush Aggarwal, Dipanwita Biswas, Vanita Sarin, Suvradeep Mitra, Ashwani Sood

Published in

Clinical nuclear medicine. Jul 21, 2026. Epub Jul 21, 2026.

Abstract

Differentiated thyroid carcinoma (DTC) metastasizes frequently to lymph nodes, lungs, and bones; however, muscle metastasis is a very rare manifestation in DTC and has never been reported in poorly differentiated thyroid carcinomas (PDTCs). Whole-body iodine scans are done postsurgery for staging and iodine avidity at residual/metastatic sites in patients of thyroid cancer. Iodine-avid muscle deposits may mimic bone metastases on whole-body iodine-131 planar imaging. SPECT/CT plays an important role in the localisation of abnormal tracer activity. Moreover, the existing data on iodine avidity of PDTC is variable. We present a case with PDTC with multifocal radioiodine-avid muscle metastases mimicking as skeletal metastases.

PMID:
42545156
Bibliographic data and abstract were imported from PubMed on 03 Aug 2026.

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