Authors
M Naeem, D V Bourassa
Published in
Probiotics and antimicrobial proteins. Aug 03, 2026. Epub Aug 03, 2026.
Abstract
The search for effective antibiotic alternatives has intensified in broiler production as consumer expectations, regulatory pressures, and disease challenges continue to shape modern poultry systems. Bacillus-based probiotics have gained particular interest because their spore-forming ability ensures feed stability and survival through feed processing and gastrointestinal transit. This review consolidates current knowledge on how Bacillus probiotics influence gut ecology, physiology, and productivity in broilers, while also emphasizing their practical relevance in commercial settings. Evidence from controlled trials shows that well-characterized Bacillus strains act through multiple coordinated mechanisms, although their efficacy is highly strain-specific. These include modulation and stabilization of the intestinal microbiota, suppression of pathogenic bacteria via competition and antimicrobial metabolite production, enhancement of digestive efficiency through enzyme secretion, and stimulation of beneficial fermentation processes. These effects are often linked to improved villus structure, strengthened epithelial barrier function, and modulation of local and systemic immune responses. Improvements in growth performance and feed efficiency have been reported in numerous studies, particularly under disease challenge or environmental stress, although responses vary with probiotic strain, supplementation strategy, and production conditions. Additionally, these probiotics have shown protective effects during necrotic enteritis challenge, reducing lesion severity and pathogen load. However, results vary across studies, influenced by strain type, dose, diet, challenge status, and farm conditions. Proper strain selection, quality control, verification of spore viability, and safety assessment are essential for reliable commercial application. In summary, current evidence supports the use of well-characterized Bacillus-based probiotics as safe and biologically effective feed additives that promote gut health, improve production efficiency, and contribute to sustainable antibiotic-reduced broiler production. Their multifaceted activity profile fits well with antibiotic-free nutrition strategies, although further research is needed to clarify strain-specific actions and optimize application protocols.
PMID:
42545609
Bibliographic data and abstract were imported from PubMed on 03 Aug 2026.
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