Diverging Clinical and Amyloid Positron Emission Tomography Features in Iatrogenic Cerebral Amyloid Angiopathy.

Authors

Nobuo Sanjo, Ryoko Muramatsu, Kota Yokoyama, Takumi Hori, Masahito Yamada

Published in

Clinical nuclear medicine. Jul 24, 2026. Epub Jul 24, 2026.

Abstract

Amyloid positron emission tomography (PET) features of cadaveric dural graft-associated iatrogenic cerebral amyloid angiopathy (iCAA) remain unclear. A 53-year-old man presented with forgetfulness and personality changes 41 years postgrafting. Cognitive test results revealed memory impairments; magnetic resonance imaging revealed medial temporal lobe atrophy, multiple microbleeds, and superficial siderosis; and amyloid PET revealed focal occipital uptake. Although focal amyloid accumulation associated with cognitive impairment has not been reported in patients with iCAA, decreased cerebrospinal fluid levels of amyloid-β 40 and 42, with normal levels of amyloid-β 42/40 ratio, p-tau 181, and total tau levels, suggest that iCAA may be a major underlying pathology.

PMID:
42545393
Bibliographic data and abstract were imported from PubMed on 03 Aug 2026.

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