Association of the triglyceride glucose-Chinese visceral adiposity index with incident sarcopenia among middle-aged and older adults with diabetes: a prospective cohort study.

Authors

Yan Chen, Tingyu Gao, Jing Gao, Xiaodong Feng

Published in

Endocrine. Volume 91. Issue 1. Aug 03, 2026. Epub Aug 03, 2026.

Abstract

Longitudinal association of triglyceride glucose-Chinese visceral adiposity index (TyG-CVAI) with the risk of new-onset sarcopenia in middle-aged and older adults with diabetes remains unclear. This study aimed to investigate whether baseline and cumulative TyG-CVAI is associated with incident sarcopenia risk in middle-aged and older adults with diabetes.
We included participants aged ≥ 50 years with diabetes from the China Health and Retirement Longitudinal Study (CHARLS) 2011-2012. TyG-CVAI was calculated as TyG index multiplied by CVAI. Multivariable Cox regression and logistic regression were used to examine the associations of baseline and cumulative TyG-CVAI with new-onset sarcopenia. Receiver operating characteristic (ROC) curves were employed to compare the predictive capability of TyG-CVAI with its individual components.
A total of 763 participants with diabetes were included in the baseline analysis. During the 4-year follow-up, 62 (8.1%) participants developed new-onset sarcopenia. Compared with the lowest quartile (Q1) of baseline TyG-CVAI, the highest quartile (Q4) was significantly associated with an increased risk of sarcopenia (HR = 2.368, 95% CI: 1.014-5.532) in the fully adjusted model, with a significant trend across quartiles (P for trend = 0.017). Compared with the low-stable group (Cluster 1, n = 198), the high-stable group (Cluster 2, n = 276) had a significantly higher risk of new-onset sarcopenia (OR = 1.100, 95% CI: 1.020-1.321). The predictive performance of baseline TyG-CVAI (AUC = 0.685, 95% CI: 0.611-0.747) and cumulative TyG-CVAI (AUC = 0.917, 95% CI: 0.845-0.962) was higher than that of baseline and cumulative TyG and CVAI.
Elevated baseline and cumulative TyG-CVAI are associated with new-onset sarcopenia in middle-aged and older Chinese adults with diabetes.

PMID:
42545547
Bibliographic data and abstract were imported from PubMed on 03 Aug 2026.

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