Molecularly imprinted electrochemiluminescence sensor based on a Co/Zn-MOF@POMs composite for sensitive and selective detection of fumonisin B1.

Authors

Zhenghong Zhao, Jinling Pu, Shuzhen Xu, Yue Xu, Zihao Huang, Lianming Zhang, Xiaoping Wei, Jianping Li

Published in

The Analyst. Aug 03, 2026. Epub Aug 03, 2026.

Abstract

Fumonisin B1 (FB1), a highly toxic secondary metabolite produced by Fusarium fungi, poses a significant threat to global food safety; therefore, sensitive, selective, and reliable analytical methods are urgently needed. In this work, we report a novel molecularly imprinted electrochemiluminescence (ECL) sensor for the quantitative determination of FB1. A Co/Zn bimetallic metal-organic framework@polyoxometalate (Co/Zn-MOF@POMs) nanocomposite was synthesized via a one-pot strategy and used to modify a glassy carbon electrode. The incorporated polyoxometalates (POMs) markedly improved the interfacial electron-transfer kinetics of the Co/Zn-MOF scaffold, resulting in substantial amplification of the ECL signal generated by ZnAgInS quantum dots (QDs). Subsequently, a molecularly imprinted polymer (MIP) layer was electropolymerized on the modified electrode using o-phenylenediamine as the functional monomer and 1,2,3-propanetricarboxylic acid as a structural dummy template designed to mimic key topological and functional features of FB1. Upon FB1 rebinding, the exposed amine groups on the captured FB1 molecules underwent a condensation reaction with carboxyl-functionalized ZnAgInS QDs, enabling site-specific immobilization of the luminophores close to the recognition cavities. Under optimized conditions, the sensor exhibited a linear ECL response to FB1 over a concentration range of 6.0 × 10^-14 to 1.0 × 10^-10 mol L^-1 (R² = 0.9987), with a detection limit of 3.3 × 10^-15 mol L^-1 (S/N = 3). This approach offers a robust and reproducible platform for trace-level FB1 monitoring in real-world food and agricultural samples.

PMID:
42545468
Bibliographic data and abstract were imported from PubMed on 03 Aug 2026.

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