Authors
Fei Wang, Liqun Shi, Yu Zhang, Zhong Lu, Xinyu Yan
Published in
Journal of visualized experiments : JoVE. Issue 233. Jul 14, 2026. Epub Jul 14, 2026.
Abstract
Breast cancer is the second most common malignant tumor in the world, seriously threatening the lives of women and imposing a huge economic burden. This study aims to explore the value of miR-362-3p combined with Doppler ultrasound in the diagnosis of breast cancer. A total of 182 breast cancer patients and 147 patients with benign breast disease were included in this study. The plasma miR-362-3p levels of the patients were measured using Real-time fluorescence quantitative polymerase chain reaction (RT-qPCR). The chi-square test was used to analyze the differences in the parameters of Doppler ultrasound between the two groups of patients. The receiver operator characteristic (ROC) curve was used to evaluate the diagnostic effectiveness of miR-362-3p, Resistance Index (RI), and Pulsatility Index (PI). The diagnostic efficiency of Doppler ultrasound combined with plasma miR-362-3p in breast cancer was analyzed through the fourfold table method. The miR-362-3p levels were markedly decreased in breast cancer patients. There were significant differences in two-dimensional ultrasound parameters. miR-362-3p, RI, and PI have diagnostic value for breast cancer. The combined diagnostic value of the three factors was higher. Ultrasound combined with miR-362-3p significantly improved the sensitivity, accuracy, and negative predictive value in breast cancer diagnosis. Doppler ultrasound combined with miR-362-3p could enhance the diagnostic efficiency of breast cancer, which may provide a non-invasive and potential auxiliary diagnostic tool for breast cancer.
PMID:
42546079
Bibliographic data and abstract were imported from PubMed on 04 Aug 2026.
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